pentobarbital will reduce the level or impact of voriconazole by impacting hepatic enzyme CYP2C9/10 metabolism. Slight/Significance Mysterious.
Monitor Closely (two)pentobarbital will lessen the extent or effect of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Solid CYP3A4 inducers may well lower suvorexant efficacy; if increased suvorexant dose demanded, never exceed twenty mg/working day
pentobarbital will lower the level or effect of maraviroc by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will minimize the level or result of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic result of elbasvir/grazoprevir may be decreased if coadministered with potent CYP3A inducers and is also hence contraindicated.
pentobarbital will minimize the extent or outcome of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a lower in fentanyl plasma concentrations, insufficient efficacy or, probably, enhancement of a withdrawal syndrome in a very client who's got made physical dependence to fentanyl.
pentobarbital increases toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers could increase the metabolism of ifosfamide to its Energetic alkylating metabolites.
Keep an eye on Intently (1)pentobarbital will here lower the level or effect of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Warning when discontinuing CYP3A4 inducers which might be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone might maximize and can lead to perhaps fatal respiratory despair.
pentobarbital will reduce the level or influence of buspirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will decrease the extent or influence of sulfamethoxazole by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Importance Not known.
pentobarbital will minimize the extent or outcome of clozapine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will minimize the extent or outcome of quinine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unidentified.
pentobarbital will decrease the extent or effect of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
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pentobarbital will decrease the extent or outcome of propafenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.